Richard Oram

Diabetes UK Harry Keen Fellow Senior Clinical Lecturer

University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter-UK

Richard is a Diabetes UK Harry Keen Fellow and Senior Clinical Lecturer specializing in nephology, diabetes and transplantation at the NIHR Exeter Clinical Research Facility. Richard finished his Diabetes UK funded PhD in 2014. He studies endogenous insulin production in people with type 1 diabetes. Using a new method developed by the NIHR Exeter team (urine C-peptide creatinine ratio), and using patients recruited as part of the Wellcome funded UNITED study, he studied endogenous insulin production in 1500 patients with type 1 diabetes and showed that most people with type 1 diabetes still make small amounts of their own insulin. He is now an Investigator on the JDRF funded TIGI study to look at mechanisms of persistent C-peptide secretion in Type 1 diabetes. Working with Mike Weedon he has developed a cheap simple method to assess genetic risk in type 1 diabetes – The T1D genetic risk score (T1D GRS). He has shown this can be used as a diagnostic test to differentiate type 1 and type 2 diabetes, and with Kash Patel has shown it can be used to identify monogenic diabetes. Recently Diabetes UK awarded Mike Weedon a project grant to further translate the T1D GRS into a tool that could be used in routine clinical care. With MIke Weedon, Bill Hagopian and the NIH funded SEARCH study, Richard is working of uses of the T1D GRS in the US population. The recent Harry Keen Career Development award and a Helmsley Foundation Breakthrough Grant funds him to study the causes of a rare subtype of type 1 diabetes - those who are diagnosed under the age of 1 year. Richard spent a period of his training at the University of Alberta with the world leading clinical islet transplant renal transplant programs. During this time he performed analysis of complications related to immunosuppression post-islet transplantation, and with Peter Senior and Shareen Forbes developed a new method to assess graft function - The Beta2 Score.