Masayuki Yamamoto


Tohoku Medical Megabank Organization

Masayuki Yamamoto graduated from Tohoku University School of Medicine and Graduate School of Medicine. In 1983, he obtained Doctor of Medical Sciences. In 1983-1986, Yamamoto was a postdoctoral fellow at Northwestern University with Professor Doug Engel, and cloned erythroid-type 5-aminllevulinate synthase (ALAS2) cDNA. In 1989, Yamamoto revisited the Engel laboratory and in collaboration identified the GATA family of transcription factors, one of the prototype transcription factor families regulating lineage commitment and cell differentiation. In 1991, Yamamoto returned to Japan and started analyses of the Gata1 and Gata2 genes. In 1995, Yamamoto became a Professor at University of Tsukuba and started a series of analyses on CNC and sMaf family of transcription factors. He identified KEAP1-NRF2 system regulating cellular response against electrophilic and oxidative stresses. Yamamoto was awarded with the Purple Ribbon (2012) medal and the Japan Academy Prize (2014). In 2012, he started Tohoku Medical Megabank Project for creative reconstruction of the Tohoku area from the devastating earthquake and tsunami occurred on March 11, 2011. The project aims to establish two types of genome cohorts and an integrated biobank.