Investigator - Human Disease Genetics
Sidra Medical and Research Center, Qatar
Dr. Khalid Fakhro is Principal Investigator at Sidra Medical and Research Center. He obtained his Bachelor’s degree with honors in Cell Biology and Molecular Genetics from the University of Chicago where his research focused on developing a doxycycline-inducible mouse model of Parkinson’s disease. He subsequently pursued his PhD in Human Genetics at Yale University, where he was part of a highly selective Howard Hughes Medical Scholars program focused on studying the basic molecular underpinnings of human disease. During his PhD training, Dr. Fakhro gained first-hand experience with multiple high-throughput data generating platforms including a range of high-density genotyping microarrays and next-generation sequencing platforms, as well the use of multiple model organisms to study human disease. Currently, his work focuses on employing new genomics technologies to discover responsible genes in patients with Mendelian disease and previously undescribed congenital syndromes. Dr. Fakhro has first-hand experience with bioinformatics analysis of large-scale genomics data, including calling multiple classes of human disease mutations such as single nucleotide and copy number variants. Additionally, due to his interest in understanding the pathophysiology of genetic disease, Dr. Fakhro is working on developing the frog animal model for use as a high-throughput tool for functional studies of genetic mutations. Finally, Dr. Fakhro is highly active in the population genomics sector in Qatar, leading multiple studies that describe variation, ancestry and predisposition to disease from sequencing over one thousand Qataris. His work positions him at the intersection of basic science research and clinical investigation and he has therefore developed collaborations with many local stakeholders including physicians and scientists at Hamad Medical Corporation, Hamad Bin Khalifa University, Qatar Biobank, and Qatar’s National Genome Program. Dr. Fakhro holds an appointment as an Assistant Professor at Weill Cornell Medical College-Qatar in the Department of Genetic Medicine, where he teaches, maintains active research collaborations and mentors students through the Nationals Program.