John Tsang

Director of Computational Systems Biology

Trans-NIH Center for Human Immunology

Dr. Tsang received his PhD in biophysics from Harvard University and BASc and MMath in computer engineering and computer science, respectively, from the University of Waterloo in Canada. Dr. Tsang has been working on systems biology and genomics research in both academic and industrial settings for over a decade. After graduating from Waterloo in 2000, he helped pioneer high-throughput computational and experimental methods to annotate the then-freshly sequenced human genome using custom DNA microarrays at Rosetta Inpharmatics and then led a bioinformatics group at Caprion Proteomics. His doctoral research was conducted in Alexander van Oudenaarden’s laboratory at the Massachusetts Institute of Technology (MIT) where he led research on the systems biology of microRNA-mediated regulation and stochastic gene expression. After earning his PhD in 2008, he returned to the Rosetta Inpharmatics (then a division within Merck Research Laboratories) to work with Dr. Eric Schadt and his group on integrative genomics and genetics of gene expression in human and mouse. He currently leads a research program developing and applying a combination of computational and experimental approaches to study the immune system (aka “systems immunology”). He is also jointly appointed as the director of computational systems biology at the Trans-NIH Center for Human Immunology (CHI), where he founded and leads a group of computational biologists integrating, analyzing and modeling large-scale data sets to study the human immune system in health and disease.