Antonio Scialdone

Junior Group Leader

Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München

Junior Group Leader at the Helmholtz Zentrum München (HMGU), where he started my lab in 2017. In their lab, they use a multidisciplinary approach to understand the fundamental biological processes behind cellular decision making. Recently developed experimental techniques have made it possible to generate a vast amount of large-scale biological data at the single-cell level. By using state-of-the-art and newly developed computational methods, they combine information obtained from the analysis of these data with the insights offered by physical models that can guide interpretation. They work in collaboration with several experimental groups, focusing on biological questions concerning different systems, like mouse embryos and mouse olfaction. Prior to joining the HMGU, he was a postdoctoral researcher at the John Innes Centre in Norwich, UK, where he used mathematical models to study the control of resource utilization in plant cells. Afterwards, he worked in single-cell genomics as a postdoctoral fellow at the Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute in Cambridge, UK. There, he has pioneered the development of computational tools for analysing single-cell RNA-sequencing data. In parallel, he has applied these tools to understand cellular fate decisions in early embryonic development, in collaboration with several experimental groups. Moreover, he co-developed a new, ligation-free technology (GAM) to map DNA physical contacts genome-wide in the cell nucleus, based on the statistical reconstruction of co-segregation frequencies of sequenced genomic regions extracted from nuclear sections.